Context and Definition

Anaphylaxis is a life-threatening hypersensitivity reaction with rapid onset which causes airway, breathing and/ or circulation problems.

  • There are 20-30 deaths each year in the UK reported as anaphylaxis but this is likely to be underestimated. [1]
  • The incidence of anaphylaxis is increasing. [1]
  • The early recognition of anaphylaxis and its prompt treatment with adrenaline, is highly likely to prevent deterioration.
  • No randomised controlled trials regarding the critical management of anaphylaxis exist, or are likely to exist.