Role of Liver (including Liver Disease and Starvation)

  • Liver cells are vital for storage of glycogen and subsequent production of glucose via glycogenolyisis.
  • Gluconeogenesis is the process by which glucose is produced from non-carbohydrate substrates including protein and lipids.
  • Diseases which reduce ability of liver cells to produce glucose through either glycogenolysis or gluconeogenesis increase the risk of hypoglycaemia e.g. alcoholic liver disease, cirrhosis, hepatitis.