Cellulitis: Aetiology

Cellulitis is an acute, spreading bacterial infection of the dermis and subcutaneous tissue, usually complicating a wound, ulcer, or dermatitis.

Affected skin becomes tender, warm, erythaematous and swollen. Any age group may be affected and numerous organisms can cause it.

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Erysipelas

Erysipelas is an acute superficial cellulitis with invasion of the lymphatics. It is generally caused by Streptococci, especially Streptococcus pyogenes. Lesions are classically well-demarcated, fiery red and raised. A ‘peau d’orange’ appearance (dimpling) is due to tethering of hair follicles within the oedematous dermis. Infants and the elderly are more commonly affected.

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Common causes of cellulitis

The common causes of cellulitis are shown in Table 1.

Common causes

Type of infection

  • Streptococcus pyogenes
  • Staphylococcus aureus
  • Cellulitis or erysipelas abscesses
  • Penetrating trauma
  • IV line sepsis
  • IV drug abuse
  • Secondary infection of damaged skin (dermatitis, burns)

Atypical causes of cellulitis

The atypical causes of cellulitis are shown in Table 2.

Atypical organisms

Common source of organisms

  • Pasteurella multocida
  • Vibrio vulnificus
  • Aeromonas hydrophila
  • Streptococcus iniae
  • Cat bites
  • Sea water
  • Fresh water
  • Fish farms

Learning bite

Atypical organisms can cause severe, rapidly progressive cellulitis with marked systemic features.