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Summarise the paper in 200 words.
What are the strengths of this study design?
Define bias and name three sources of bias that could have been introduced into this study.
What is a PROBE (Prospective Randomised Open Blinded Endpoint) study?
What is the rationale for an intention-to-treat analysis?
In table 1, was there any differences in baseline characteristics between the study groups? Why is this important?
Calculate the hazard ratio for patients re-presenting or being readmitted to hospital between the intervention and control groups.
Please see the following excerpt from the paper:
“The primary endpoint occurred in 51 (5.8%) participants randomised to CT coronary angiography and 53 (6.1%) participants who received standard of care only (adjusted hazard ratio 0.91 (95% confidence interval 0.62 to 1.35)”.
How should the confidence interval be interpreted here?