Authors: Christopher Manville / Editor: Frances Balmer / Codes: / Published: 27/06/2022
Kawasaki disease is a leading cause of acquired heart disease in children in the UK, yet diagnosis is all too often missed or delayed.
This learning session aims to increase the awareness of Kawasaki disease with a focus on recognising the principal clinical features, in line with recent updates to the NICE guidelines. The session is aimed at emergency medicine clinicians with a focus on early recognition, initial investigations and the treatment of Kawasaki disease.
Learning objectives:
- Understand the epidemiology of Kawasaki disease
- Recognise the signs and symptoms of Kawasaki disease
- Outline investigations used in the work up of a patient with suspected Kawasaki disease
- Outline the initial management of Kawasaki disease
- Describe the main complications of Kawasaki disease
References
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- Kawasaki T. [Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children]. Arerugi. 1967;16(3):178-222.
- McCrindle BW, Rowley AH, Newburger JW, Burns JC, et al. Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association. Circulation. 2017;135(17):e927-e99.
- Modesti A, Plewa M. Kawasaki Disease StatPearls [Internet]: Treasure Island (FL); 2021 [Image courtesy S Bhimji MD].
- Rife E, Gedalia A. Kawasaki Disease: an Update. Curr Rheumatol Rep. 2020;22(10):75.
- Noval Rivas M, Arditi M. Kawasaki disease: pathophysiology and insights from mouse models. Nat Rev Rheumatol. 2020;16(7):391-405.
- Abrams JY, Weintraub ES, Baggs JM, McCarthy NL, et al. Childhood vaccines and Kawasaki disease, Vaccine Safety Datalink, 1996-2006. Vaccine. 2015;33(2):382-7.
- Baker MA, Baer B, Kulldorff M, Zichittella L, et al. Kawasaki disease and 13-valent pneumococcal conjugate vaccination among young children: A self-controlled risk interval and cohort study with null results. PLoS Med. 2019;16(7):e1002844.
- Hall GC, Tulloh RM, Tulloh LE. The incidence of Kawasaki disease after vaccination within the UK pre-school National Immunisation Programme: an observational THIN database study. Pharmacoepidemiol Drug Saf. 2016;25(11):1331-6.
- Yung CF, Ma X, Cheung YB, Oh BK, Soh S, Thoon KC. Kawasaki Disease following administration of 13-valent pneumococcal conjugate vaccine in young children. Sci Rep. 2019;9(1):14705.
- Trager JD. Images in clinical medicine. Kawasaki’s disease. N Engl J Med. 1995;333(21):1391.
- Association AH. Kawasaki Disease: Signs, Symptoms and Diagnosis.2020 [Photos courtesy of Kawasaki Disease Foundation].
- Cadogan M, Laud R. Kawasaki disease. Life In The Fast Lane. 2020
- Eleftheriou D, Levin M, Shingadia D, et al. Management of Kawasaki disease. Arch Dis Child. 2014;99(1):74-83.
Additional resources
- Kawasaki Disease Foundation
- Societi – The UK Kawasaki Disease Foundation
