Pancreatitis

Author: Oliver Daly / Editor: John Scanlon / Reviewer: Jennifer Lockwood, Mehdi Teeli / Codes: A3 / Published: 18/10/2021

By the end of this session you will be able to:

  • Elicit the features on history and examination that suggest a diagnosis of pancreatitis in a patient with abdominal pain
  • Describe the aetiology and pathophysiology of pancreatitis
  • Perform a risk assessment in a patient presenting with suspected pancreatitis
  • Order and interpret appropriate laboratory tests and imaging in patients with suspected pancreatitis
  • Institute appropriate initial management and describe the ongoing care of a patient with pancreatitis
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References

  1. Khanna AK, Meher S, Prakash S, et al., Comparison of Ranson, Glasgow, MOSS, SIRS, BISAP, APACHE-II, CTSI Scores, IL-6, CRP, and Procalcitonin in Predicting Severity, Organ Failure, Pancreatic Necrosis, and Mortality in Acute Pancreatitis. HPB Surg. 2013;2013:367581.
  2. Toh SK, Phillips S, Johnson CD. A prospective audit against national standards of the presentation and management of acute pancreatitis in the South of England. Gut 2000;46:23943.
  3. Corfield AP, Cooper MJ, Williamson RC. Acute pancreatitis: a lethal disease of increasing incidence. Gut 1985;26:7249.
  4. UK Working Party on Acute Pancreatitis. UK guidelines for the management of acute pancreatitis, Gut 2005;54:1-9.
  5. JA Marx, RS Hockberger, RM Walls. Rosens Emergency Medicine: Concepts and Clinical Practice. C.V. Mosby; 5th edition 2002.
  6. Bradley EL 3rd. A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, GA, September 11 through 13, 1992. Arch Surg 1993;128:58690.
  7. JE Tintinalli, GD Kelen, JS Stapczynski. Emergency Medicine: A Comprehensive Study Guide. American College of Emergency Physicians. McGraw-Hill Professional Publishing; 5th edition 1999.
  8. JA Marx, RS Hockberger, RM Walls. Rosens Emergency Medicine: Concepts and Clinical Practice. C.V. Mosby; 5th edition 2002.
  9. Toouli J, Brook-Smith M, Bassi C, et al., Guidelines for the management of acute pancreatitis. J Gastroenterol Hepatol 2002;(Suppl 17):S1539.
  10. JA Marx, RS Hockberger, RM Walls. Rosens Emergency Medicine: Concepts and Clinical Practice. C.V. Mosby; 5th edition 2002.
  11. Kwon RS, Banks PA. How should acute pancreatitis be diagnosed in clinical practice? In: Dom nguez-Munoz JE, ed. Clinical Pancreatology for practicing gastroenterologists and surgeons. Malden, MA: Blackwell, 2005;4:349.
  12. UK Working Party on Acute Pancretitis. UK guidelines for the management of acute pancreatitis, Gut 2005;54:1-9.
  13. JA Marx, RS Hockberger, RM Walls. Rosens Emergency Medicine: Concepts and Clinical Practice. C.V. Mosby; 5th edition 2002.
  14. National Institute for Health and Care Excellence, Pancreatitis -NICE guideline [NG104]. Published: 05 September 2018. Last updated: 16 December 2020.
  15. Imrie CW, Benjamin IS, Ferguson JC, et al., A single-centre double-blind trial of Trasylol therapy in primary acute pancreatitis. Br J Surg. 1978 May;65(5):337-41.
  16. Rompianesi G, Hann A, Komolafe O, et al., Serum amylase and lipase and urinary trypsinogen and amylase for diagnosis of acute pancreatitis. Cochrane Database Syst Rev. 2017 Apr 21;4(4):CD012010.
  17. Chang K, Lu W, Zhang K, et al., Rapid urinary trypsinogen-2 test in the early diagnosis of acute pancreatitis: a meta-analysis. Clin Biochem. 2012 Sep;45(13-14):1051-6.
  18. Aoun E, Chen J, Reighard D, et al., Diagnostic accuracy of interleukin-6 and interleukin-8 in predicting severe acute pancreatitis: a meta-analysis. Pancreatology. 2009;9(6):777-85.

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